In the mouse model of non-small cell lung cancer, STK11 mutation is related to “cold” immunosuppressive tumor microenvironment, showing a decrease in the expression of immune inflammatory factors (CD8+ and CD4+T lymphocytes, type 1 macrophages) and PD-L1, and an increase in T cell failure markers and tumor-promoting cytokines (32). The gene discussed is CD274; the disease is non-small cell lung carcinoma.