HPSE and renal carcinoma: For example, CHRBP (Corticotropin releasing hormone binding protein) secreted by myeloid components could inhibit renal carcinoma progression (20); HPSE (Heparanase) secreted by myeloid components could promote the degradation of ECM, which further promotes the infiltration of T lymphocytes and hence antitumor ability (21); SLAMF1 (Signaling lymphocytic activation molecule family member 1) secreted by lymphocyte components could promote M1 macrophage anti-tumor polarization (22); SLAMF1 could also promote the infiltration and activation of certain T and B lymphocytes (23, 24).