RAG1 and Chronic colitis: To explore the interaction between MDSCs and T cells, Kurmaeva et al. isolated CD11b+Ly6G-Ly6Chigh MDSCs, namely M-MDSCs from recombination-activating gene 1 deficient (RAG-1-/-) mice with chronic colitis induced by T cell transfer, and added the group of M-MDSCs to activated CD4+ T cells in vitro (55).