Similarly, induction of less severe TNBS-colitis in TNBS-colitis-resistant C57BL/6 mice (with in this case administration of 3.75 mg/mouse) led to more severe disease in mice bearing a BS-NOD2 transgene than in either mice bearing a CD-frameshift NOD2 transgene or a WT B6 mice bearing no transgene, whereas mice bearing a CD-frameshift NOD2 and WT B6 mice bearing no transgene exhibited colitis of equal severity (Supplementary Figures 3A, B). The gene discussed is NOD2; the disease is colitis.