In addition, MDP stimulation of either peripheral blood monocytes or monocyte-derived dendritic cells (MoDCs) and macrophages (MoMacs) from patients with BS who are heterozygous carriers of the Blau mutation (Figure 5B) resulted in far greater reductions in cytokine responses than could be explained by simply having one rather than two alleles encoding NOD2 (Figures 5C–E). The gene discussed is NOD2; the disease is Bloom syndrome.