The key finding here was that mouse cells did not exhibit heightened cytokine responses or MAPK/NF-κB responses in the absence of stimulation and exhibited reduced responses following stimulation with MDP; similarly, cells from patients with Blau syndrome did not exhibit increased cytokine production in the absence of MDP stimulation and did exhibit reduced response with MDP stimulation. This evidence concerns the gene NFKB1 and Blau syndrome.