The levels of NLRP3 mRNA in steroid resistant asthmatics correlate with the numbers of neutrophils, and the severity of asthma (140), while levels of IL-1 β correlate with IL-8, a neutrophil attracting chemokine (141), suggesting a role of NLRP3 in the neutrophil asthma phenotype. The gene discussed is CXCL8; the disease is asthma.