A Korean study showed that acupuncture at GB34 and LR3 might inhibit the degeneration of dopamine neurons in the SN of MPTP-induced Parkinson’s disease mouse model, and the affymetrix gene chip test showed that PPBP was upregulated in MPTP group compared with control; however, compared with the MPTP group without acupuncture, PPBP was downregulated after acupuncture, indicating that PPBP may be involved in the pathogenesis and regulation of PD (42). Here, PPBP is linked to Parkinson disease.