Tregs can block cytotoxic CD8+ T lymphocytes (CTLs) cytotoxic and proliferative capabilities, aid in the creation of an immunosuppressive TME, and are linked to the advancement of HCC (9), while CD8+ T cells specific for neoantigens are more resistant to Treg cell-mediated immune suppression (10). Here, CD8A is linked to hepatocellular carcinoma.