VSIG2 and Fuchs endothelial corneal dystrophy: VSIG2 was found to be significantly upregulated in the corneal samples of Fuchs endothelial corneal dystrophy (FECD) patients (53), in the intestinal biopsy of irritable bowel syndrome (IBS-D) patients (54), in the plasma of acute tubular injury and interstitial fibrosis/tubular atrophy patients (55), and in the plasma of incident heart failure patients (56).