EIF2AK3 and neoplasm: Furthermore, the PERK signaling via transcription factor CCAAT/enhancer binding protein δ (C/EBPδ) has been associated with tumors by the action of chemokines such as CXCL8, and C-C motif chemokine ligand 20 (CCL20), which have been related to tumor-promotion with immunosuppressive properties and are triggered by activated oncogenes, nutrient deprivation, and hypoxia (140).