VIM and lung adenocarcinoma: Reversibility of TGF-β1-induced expression of TGF-β1-responsive genes, collagen type I alpha 1 chain (COL1A1), vimentin (VIM), and E-cadherin (CDH1),37 were examined upon addition of APT-β1-OMe-P/APT-β1-OMe in human lung adenocarcinoma A549 cells that were pre-treated with 0.4 nM TGF-β1 (Figure 3A).