KL and sarcopenia: Notably, the anti-aging effects of Klotho have been partially attributed to modulation of the renin-angiotensin system (RAS), Wnt, mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK) pathways (92, 96, 119, 120), some of which are also mechanistic targets for these sarcopenia treatments.