In addition, many stool-based methylation biomarkers are known to detect CRC earlier, including hypermethylated HLTF, WIF1,APC,VIM,BMP3,TFPI2,ATM,RASSF2A,SFRP2,NDRG4,CDKN2A,MGMT,GATA4,MLH1, andGSTP1genes, which were reviewed by several publications.12, 16. This evidence concerns the gene HLTF and colorectal carcinoma.