There are many genes that can be utilized as blood-based methylation markers to be able to detect CRC such asRUNX3,APC,SEPT9,MGMT,WIF1,hMLH1,RASSF2A,HLTF,VIM,ALX4,SFRP2,NGFR,NEUROG1, andTMEFF2, while their range of sensitiveness and specificities are respectively 34 to 90% and 69 to 100%.12The methylatedSEPT9gene is recently identified as a strong potential blood-based methylation biomarker in the case of distinguishing which samples are cancerous or not via high rate of specificity and sensitivity (respectively 90 and 72%) compared with other markers. The gene discussed is MLH1; the disease is colorectal carcinoma.