HLTF and colorectal carcinoma: Distinct pathological and molecular properties are found in CIMP-positive tumors, including a tendency for female gender, mucinous and poor histology, proximal location in the colon, and frequent mutations (KRAS and BRAF).10Suppression of DNA repair genes and tumor suppressor genes includingMGMT SEMA3F,APC2,SLC5A8,MLH1,ITGA4,CDKN2A P16,SFRP2,HLTF, andPTCH1act significantly during progression adenomas to CRC.11