Aa for 2) Diabetic nephropaty, BAE rescued renal fibrosis via modulating AngII, TGF–β, α-SMA protein expression as well as p38MAPK/NF-κB transduction while WGS and WGI both negatively-regulated TLR4/NF-κB to protect renal tissue. This evidence concerns the gene NFKB1 and renal fibrosis.