Diabetic food ulcer is another complication of T1DM, the pathogenesis of which is proven to be correlated with elevated NO, MDA, p-ERK and p-HSP27 while decreased level of SOD, GSH, VEGF-c, Ang-1, Tie-2, TGF-β and Smad2/3. The gene discussed is SOD1; the disease is type 1 diabetes mellitus.