TNF and Arthritis: BAI also lowered relevant proinflammatory cytokines including TNF-α, IL-1β, IL-6, MMP-2, MMP-9, NO and COX-2 secretions in e synovial fluids and tissues of CIA rats to interfere JAK/STAT signaling transduction, which attributed to its restoring of pressure pain thresholds and clinical arthritis scores (Wang G. et al., 2018).