In mice model of collagen-induced arthritis (CIA) which is widely used to mimic joint inflammatory symptoms in human RA (Wu et al., 2022), BAI treatment alleviated radiographic and histologic abnormalities in the hind paw joints of CIA rats, and the underlying mechanism was associated with its modulation on TLR2/MYD88/NF-κB p65 signaling as well as the blockage of IL-1β, TNF-α and IL-6 production (Wang H. Z. et al., 2014; Xu et al., 2018; Bai et al., 2020). Here, TNF is linked to rheumatoid arthritis.