Not only were PCSK6 plaque levels increased in patients with previous myocardial infarction and patients undergoing carotid endarterectomy with stroke symptoms, but the positive correlation observed with MATX components and LRNC volume suggests a possible role of PCSK6 in plaque vulnerability (Testa et al., 2021; Perisic et al., 2013). The gene discussed is PCSK6; the disease is myocardial infarction.