Our data aligns with a recent report by Kuhn et al identifying PCSK6 as a novel player in cardiac remodeling after myocardial infarction (Kuhn et al., 2020), but also with a more recent report showing that Pcsk6 deficiency results in cardiomyocyte senescence (Zhan et al., 2022) that confirmed our findings in primary vascular SMCs isolated from Pcsk6 knockouts (Rykaczewska et al., 2020). Here, PCSK6 is linked to myocardial infarction.