INS and diabetes mellitus: Genetic analyses showed that variants in the genomic regions of PCSK1 and PCSK2 associate with CVD traits, confirming previous reports about the involvement of these genes in obesity and diabetes (O'Rahilly et al., 1995; Jackson et al., 1997), glucose homeostasis (Leak et al., 2007; Chang et al., 2015) and insulin secretion (Jonsson et al., 2012).