As reported in a study, SETD1A activates MMP levels to modulate BC metastasis (Salz et al., 2015), and another study suggests that SETD1A amplification within mixed ductal and lobular breast cancer can upregulate the H3K4me3 marker to modulate mitosis within the mitosis and DNA damage response gene promoters. This evidence concerns the gene SETD1A and breast cancer.