EZH2 and breast cancer: It is interesting that H3K27me3 is related to EZH2 upregulation in TNBC and basal-like BC, indicating the role of enhanced EZH2 activity in functions associated with non-H3K27 methylation, such as specifically regulating ubiquitination and transcription factors (TFs), and protein decomposition inducing tumor genesis and development (Park et al., 2021).