It is interesting that H3K27me3 is related to EZH2 upregulation in TNBC and basal-like BC, indicating the role of enhanced EZH2 activity in functions associated with non-H3K27 methylation, such as specifically regulating ubiquitination and transcription factors (TFs), and protein decomposition inducing tumor genesis and development (Park et al., 2021). This evidence concerns the gene EZH2 and neoplasm.