In summary, there is a close relationship between polysaccharide metabolism and the development of osteoporosis, so we speculate that the proteins k07968, k01197, k03909, and genes B4GALT3, HYAL2, and TFPI may have relevance in the regulation of multiple signaling pathways by polysaccharide metabolism in the development of osteoporosis. The gene discussed is HYAL2; the disease is osteoporosis.