The protein expressions of TLR4 (−0.3800, 95% CI: −0.6417 to −0.1183, p = 0.004), MyD88 (−0.3367, 95% CI: −0.6414 to −0.0320, p = 0.027), and NF-κB (−0.3900, 95% CI: −0.5062 to −0.2738, p < 0.001) in the HD group were significantly different from those in the MC group. The gene discussed is TLR4; the disease is Huntington disease.