EGFR and non-small cell lung carcinoma: Approximately 10% of patients with NSCLC harbor uncommon EGFR alterations including major uncommon mutation G719X, L861Q and S768I (Figure 1), de novo T790M mutation and exon 20 insertions, or their compound forms including the co-existence of common or uncommon mutation (Russo et al., 2019; Zhang et al., 2019; An et al., 2020; Gristina et al., 2020).