Previous studies have shown that STAT3 can promote glycolysis metabolism of multiple malignant tumors by regulating the expression of glycolysis key enzymes and the glycolysis regulator (Ando et al., 2010; Li et al., 2017; Hanlon et al., 2019; Darnell, 2020; Valle-Mendiola and Soto-Cruz, 2020). The gene discussed is STAT3; the disease is cancer.