KCNK2 and heart disorder: Indeed, TREK channels have been related to various heart diseases (Schmidt et al., 2012; Wiedmann et al., 2016; Decher et al., 2017) and although it has been previously shown that verapamil blocks some members of the K2P family, including TRESK (Park et al., 2018) and TASK-4 (Staudacher et al., 2018), its effect on TREK channels remains unknown.