Studies (Wang et al., 2012) have confirmed that with the gradual aggravation of HF, the level of BNP also increases, and when improvements in heart function are made, the level of BNP will significantly decrease, suggesting that BNP can be used as a marker to observe the severity of HF and assess the risk stratification and prognosis of HF. The gene discussed is NPPB; the disease is hydrops fetalis.