This hypothesis is supported by the finding that MHY1485, a specific activator of the Akt-mTOR signaling pathway that affects autophagy, further impairs the motor abilities of PD mice and attenuates the beneficial effect of sinomenine on the motor abilities of PD mice by promoting the loss of dopaminergic neurons (Bao et al., 2022). The gene discussed is AKT1; the disease is Parkinson disease.