Although the remaining DEGs did not directly affect the prognosis of the two subtypes of CRC, we found that by constructing the protein interaction network of all DEGs, they could interact with CLC, GFI1, ZG16, ITLN1, CLCA1, and AQP8 and indirectly participate in the regulation of prognosis of the subtypes of CRC. This evidence concerns the gene GFI1 and colorectal carcinoma.