Although the remaining DEGs did not directly affect the prognosis of the two subtypes of CRC, we found that by constructing the protein interaction network of all DEGs, they could interact with CLC, GFI1, ZG16, ITLN1, CLCA1, and AQP8 and indirectly participate in the regulation of prognosis of the subtypes of CRC. The gene discussed is AQP8; the disease is colorectal carcinoma.