In low-grade glioma, secondary glioblastoma, and acute myelogenous leukemia, the oncogenic mutations in the two-isocitrate dehydrogenase (IDH) encoding genes (IDH1 and IDH2) have been identified (Agnihotri et al., 2013; Zhou and Wahl, 2019). The gene discussed is IDH2; the disease is glioblastoma.