In the PS-matched cohorts (excluding CUIMC, which did not achieve sufficient covariate balance), in total 6,319 alpha-1 blocker users of (275 in SIDIAP, 1,485 in VA, 4,351 in OpenClaims, 175 in Optum DOD, and 33 in Optum EHR) and 1,105 5ARI/PDE5 users (51 in SIDIAP, 236 in VA, 764 in OpenClaims, 47 in Optum DOD, and 7 in Optum EHR) were diagnosed with COVID-19. This evidence concerns the gene PDE5A and COVID-19.