An intensive connection has been shown between elevated uric acid and CVDs, and the mechanisms underlying deleterious effects of elevated uric acid on cardiovascular health included increased oxidative stress, reduced availability of nitric oxide and endothelial dysfunction, promotion of local and systemic inflammation, vasoconstriction and proliferation of vascular smooth muscle cells, insulin resistance, and metabolic dysregulation (Ndrepepa, 2018). This evidence concerns the gene INS and endothelial dysfunction.