It is important to notice that Mcl-1 also was shown to be a prominent regulator increasing sensitivity to mitotic arrest in primary mouse fibroblasts and several carcinoma cell lines sensitive to DiM due to its degradation during mitotic arrest (Harley et al., 2010; Wertz et al., 2011; Colin et al., 2015; Haschka et al., 2015). This evidence concerns the gene MCL1 and carcinoma.