TP53 and neoplasm: Recent evidence from a tumor senescence study suggested that Taz, a core component and transcriptional coactivator of Hippo signaling, could negatively regulate p53 and attenuate p53-mediated cellular senescence (Miyajima et al., 2020), which repairs the NP senescent phenotype (Fearing et al., 2019) as well as osteoporosis and skeletal aging disease (Yu et al., 2018).