Feng et al. (2016) highlighted the PKCα-mediated phosphorylation of the S112 residue of LSD1 which was crucial for epithelial-mesenchymal transition (EMT) and metastasis of BC cells. Liu et al. (2020a) found that PRMT4 methylated and stabilized LSD1 via promoting it and it binding to deubiquitinase USP7 in BC cells. Recently, Gong et al. (2021) revealed that OTUD7B could remove the Poly-Ub Chains of LSD1 at K226/277 residues, maintain the integrity of LSD1/CoREST/HDACs co-repressor complexes, and inhibit BC metastasis. This evidence concerns the gene PRKCA and breast cancer.