KDM1A and cancer: Coptis chinensis, another traditional Chinese medicine widely used over 2,000 years for treatment of atherosclerosis, diabetes, and inflammation (Alami et al., 2020) has also been used to treat a varieties of cancers including BC (Wu et al., 2019), and isoquinoline alkaloids (Figure 6, 30–34) have been identified as the main anticancer active components of C. chinensis with inhibitory activity against LSD1 (Yi et al., 2016).