Furthermore, berberine can also induce Zrt-Irt-like protein 14 expression to protect the intestinal barrier in sepsis (He et al., 2019), and ameliorates sepsis-induced reduction in intestinal vascular barrier permeability caused by sepsis by modulating the ApoM/S1P pathway (Li Y. et al., 2020). Here, SLC39A14 is linked to Sepsis.