AKT1 and rheumatoid arthritis: The related 3,316 proteins’ network data showed that ErbB, HIF-1, NF-κB, FoxO, chemokines, MAPK, JAK-STAT, PI3K-AKT pathways participate in the multi-targets mechanism of HCQ in RA (Lyu et al., 2020; Xie et al., 2021).