Recent evidence suggests that the IC plays a predominant role in FXS as the deletion of Fmr1 -/- expression specifically in VGlut2 neurons both the cortex and the IC is sufficient to induce audiogenic seizure, while IC Ntsr1 specific Fmr1 deletion is necessary but not sufficient to induce audiogenic seizure in the Cortex (Gonzalez et al., 2019). The gene discussed is SLC17A6; the disease is fragile X syndrome.