The mitochondrial enzyme encoded by CPS1 catalyzes the synthesis of carbamoyl phosphate from ammonia and bicarbonate, which plays an important role in removing an excess ammonia from the cell, and is widely studied in proteomic-based research; CPS1 was upregulated by an effective treatment in insulin resistance in mice (Ham et al., 2021). The gene discussed is CPS1; the disease is Insulin resistance.