For example, COX4I1 and COX6B1 enriched in the neurodegenerative disease pathway are two subunits of cytochrome c oxidase, are an integral part of the mitochondrial machinery needed for ATP production in mammalian cells (Pajuelo et al., 2020), and are found to be overexpressed when neuronal cells are injured (Yang et al., 2019). Here, COX4I1 is linked to neurodegenerative disease.