BGLAP and Parkinson disease: Recently, a study found that Osteocalcin (OCN), an osteoblast-derived protein, was successful in reducing dopaminergic cell loss and motor deficits in a PD mouse model through modulation of the gut; OCN depleted Firmicutes and increased abundance of Bacteroidetes, and OCN’s neuroprotective effect is thought to be facilitated by propionate, a SCFA (Hou et al., 2021).