AMT and autism: Likewise, mutations in genes either encoding GlyRs (Piton et al., 2013; Pilorge et al., 2016), KCC2 (Merner et al., 2015), or the amino methyltransferase enzyme (AMT) involved in glycine degradation (Yu et al., 2013), were reported in patients affected by autism, supporting the glycine role in neurogenesis.