Due to the importance of ER stress in regulating food intake, body weight and insulin secretion (Kim et al., 2012; Ajoolabady et al., 2022), it is suggested that in SCZ, reduced DRD2 signaling may lead to induction of ER stress, and these effects may largely contribute to SCZ-associated metabolic disorders such as increased BMI and glucose metabolic disorders (Figure 3). Here, DRD2 is linked to metabolic disease.