Antipsychotic-induced weight gain/obesity is also associated with several neuropeptides or hormones that regulate energy balance and neuroendocrine function such as proopiomelanocortin (POMC), NPY, AgRP, insulin, leptin, and ghrelin (Ballon et al., 2014). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.