NPY and Glucose intolerance: It has been reported that olanzapine, clozapine, risperidone, or quetiapine could block hypothalamic H1R or 5-HT2CR, thereby activating adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) signaling and increasing neuropeptide Y (NPY) expression, which in turn leads to increased food intake, weight gain, and glucose intolerance (Ikegami et al., 2013; He et al., 2014; Wan et al., 2020).