MAPT and Alzheimer disease: Alzheimer’s disease (AD) is a multifactorial neuro-degenerative disease, which affects cognitive function and memory, is characterized by amyloid β (Aβ, formed by activities of β and γ secretase) and neurofibrillary tangles (NFTs, composed of over-phosphorylated tau protein), but its pathogenesis is not yet clear (Blennow and Zetterberg, 2018; Weller and Budson, 2018).