In addition, whether electrodiagnostic features of high-frequency RNS are specific features of some CMS subtypes (such as patients with GFPT1-related CMS in our study or patients with RAPSN-related CMS in the study by LoRusso and Iyadurai) and helpful for diagnosis deserved to be further studied, which were also greatly significant in our study. The gene discussed is RAPSN; the disease is congenital myasthenic syndrome.