CD8A and malignant colon neoplasm: Furthermore, peritumoral administration of IC-SNAs ina syngeneic mouse model of MC38 colon cancer leads to reduced sPD-L1expression in multiple cell populations within the TME, includingtumor cells, dendritic cells, and myeloid derived suppressor cells.The treatment effectively increases CD8+ T cells accumulationand functionality in the TME, which ultimately inhibits tumor growthand extends animal survival.