These compounds inhibit the transcriptional program ofFOXO3 and modulate its physiological function in the low micromolarrange in cancer cells.24,25 By NMR, we have also demonstratedthat 5ca and its oxalate salt directly interact withthe DNA-binding domain (DBD) of FOXO3, thereby blocking its DNA-bindingsurface in the α-helix H3 recognition region and in the N-terminusof β-strand S2. Here, FOXO3 is linked to cancer.