FOXO3 and cancer: Strong chemotherapy resistance often hampers the treatmentof neuroblastoma,a malignancy more prevalent among patients younger than 15 years.23 As in other cancers, one of the factors responsiblefor increased neuroblastoma chemoresistance and tumor angiogenesisis FOXO3 nuclear localization.14,15 However, no small-moleculeFOXO3 inhibitors are currently available for clinical use.