The ability of these compounds to inhibit FOXO3 transcriptionalactivity was further examined by assessing their effect on FOXO3 bindingto the promoter region of decidual protein induced by progesterone1 (DEPP1) after transfecting a DEPP1-luciferase reporter plasmid intoSH-EP neuroblastoma cells stably expressing a 4-hydroxy-tamoxifen(4OHT)-regulated FOXO3(A3)ERtm transgene. The gene discussed is FOXO3; the disease is neuroblastoma.