Conversely, 14-3-3 proteins stimulate the aggregation of unphosphorylated Tau protein, a neuronal protein involved in microtubule stabilization and a major component of intraneuronal neurofibrillary tangles in patients with Alzheimer disease (Sadik et al., 2009; Sluchanko and Gusev, 2011; Qureshi et al., 2013; Neves et al., 2021). This evidence concerns the gene YWHAQ and Alzheimer disease.