More recently, nevertheless, 14-3-3 proteins have also been shown to promote chemoresistance and poor outcomes among patients with cancer, such as breast, lung, prostate, head and neck cancer, as well as myeloma and glioblastoma (Lu et al., 2009; Xu et al., 2015; Gu et al., 2018; Lage-Vickers et al., 2021), most likely because the chromosomal region 8q22.3, which includes the 14-3-3ζ gene (YWHAZ), is regularly duplicated in cancer (Pollack et al., 2002). This evidence concerns the gene YWHAQ and cancer.