Previous studies also suggest that in most solid tumors of epithelial origin, expression of MRC2 is reported to be predominantly restricted to cancer-associated fibroblasts (CAFs) with little or no expression by the tumor cells (Sulek et al., 2007; Sulek et al., 2007; Schnack Nielsen et al., 2002; Curino et al., 2005; Koikawa et al., 2018). Here, MRC2 is linked to cancer.