The authors analyzed by microarray the transcriptome of kynurenine-treated glioma and found an AHR signature, characterized by an upregulation of AHR-target genes such as CYP1B1 (Cytochrome P450 family 1 subfamily B member 1) and TIPARP (TCDD-inducible poly-ADP-ribose polymerase). This evidence concerns the gene CYP1B1 and central nervous system cancer.