Besides, USP13 depletion dramatically inhibited cancer cell proliferation and suppressed tumor growth in xenograft models while reintroduction of MCL-1 partly restored cell proliferation and increased the tumor volume, reinforcing the regulation of MCL-1 by USP13 (Zhang et al., 2018; Wu et al., 2019; Morgan et al., 2021). The gene discussed is USP13; the disease is cancer.