In ALS, SGs colocalize with TDP-43 and poly-GR aggregates (Liu-Yesucevitz et al., 2010; Chew et al., 2019), and chronic SGs could directly contribute to ALS onset (Daigle et al., 2016; Zhang et al., 2019). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.