Intranasal immunization with recombinant Tm-WAP49 protein formulated with the combination adjuvant of OCH (the irritant of natural killer T cells) and QS-21 (Quillaja saponaria) increased the central (CD62L+CD44+) and effector (CD62L–CD44+) memory subsets of both CD4+ and CD8+ T cells and induced strong protection against murine trichuriasis (Wei et al., 2022). This evidence concerns the gene CD4 and trichuriasis.