A total of 279 pathways were enriched with 89 pathways significantly enriched (p < 0.05), of them MAPK signaling pathway (ko04010), HIF-1 signaling pathway (ko04066), and proteoglycans in cancer (ko05205) were most significantly enriched between normoxic (21% O2, TN vs. LN) and hypoxic (2% O2, TL vs. LL) groups (Figures 5A,B). This evidence concerns the gene HIF1A and cancer.