A recent study involving mice showed that TRPA1 plays a crucial role during AD pathogenesis, and that this receptor could potentially be used as a target for treating chronic skin inflammatory diseases (92); the authors showed that, in addition to lower dermal MC infiltration and proinflammatory cytokines, a lesser infiltration of macrophages was also observed in TRPA1−/− mice (compared to the wild type mice). This evidence concerns the gene TRPA1 and Alzheimer disease.