Aerobic exercise could inhibit the TLR4/NF-κB/NLRP3 signaling pathway in the dentate gyrus region of the hippocampus of post-stroke depression models (Li et al., 2020), which could prevent the activation of TXNIP and NLRP3 inflammasome pathways in AD rats (Rosa et al., 2021), and ameliorate depression-like behaviors by decreasing NLRP3, IL-1β, and IL-18 expressions in the hippocampal tissues (Wang et al., 2016c). Here, TLR4 is linked to major depressive disorder.