Lee et al. (2018) have proved that voluntary running could reduce the activation of NLRP3 inflammasome in the endothelial cells of the coronary arteries. Their findings further suggested that aerobic exercise improves the vascular function by inhibiting NLRP3 inflammasome signaling (Lee et al., 2020). Other studies also reported that treadmill exercise of >12 weeks could reduce the endothelial cell’s pyroptosis in arteriosclerosis (Hong et al., 2018; Hong et al., 2021) (as shown in Table 1). Here, NLRP3 is linked to arteriosclerosis.