The activation of the NLRP3 inflammasome could enhance the expression of IL-1β, IL-18, and interferonγ (IFNγ), while it inhibits IRS-1/PI3K/AKT signaling (Sun et al., 2017) (Vandanmagsar et al., 2011), thereby leading to insulin resistance. The gene discussed is IL18; the disease is Insulin resistance.