The activated NLRP3 inflammasome could increase the expression and release of the high-mobility histone box-1 (HMGB1) in endothelial cells (Lee et al., 2020), promoting endothelial hyperpermeability and leading endothelial dysfunction (Wang L. et al., 2016; Wang et al., 2016a). The gene discussed is NLRP3; the disease is endothelial dysfunction.