EPAS1 and metabolic dysfunction-associated steatotic liver disease: First, in the liver, hypoxia-induced overexpression of HIF-2α can inhibit fatty acid β-oxidation, thereby activating peroxisome proliferators to activate the receptor PPARα, which, in turn, induces fat formation in the liver and exacerbates nonalcoholic fatty liver disease (NAFLD) (J. Chen et al., 2019).