First, in the liver, hypoxia-induced overexpression of HIF-2α can inhibit fatty acid β-oxidation, thereby activating peroxisome proliferators to activate the receptor PPARα, which, in turn, induces fat formation in the liver and exacerbates nonalcoholic fatty liver disease (NAFLD) (J. Chen et al., 2019). The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatotic liver disease.