MCU overexpression also significantly promotes the expression of HIF-1α and vimentin, and suppresses the expression of E-cadherin in gastric cancer cells, while HIF-1α can induce the proliferation, migration, and invasion of gastric cancer cells by promoting the expression of VEGF, suggesting that MCU may regulate the expression of VEGF through HIF-1α. The gene discussed is VEGFA; the disease is gastric cancer.